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7 . Any general comments about
the method?
The method is straightforward and clear for all three matrices. For dietary
supplement the procedure is simple Peaks are well separated in chromatogram
,
.
.
This method is lack of separation of beta‐cryptoxanthin isomers and identification of
lutein and zeaxanthin.
Beta‐cryptoxanthin standard is included in the method but the purpose isn't clear.
Do you recommend this method be
adopted as a First Action and
No. This method doesn't demonstrate the capability to separate beta‐cryptoxanthin
isomers as well as other carotnoids such as lutein and zeaxznthin Thus it doesn't
V. Recommendation for the Method
published in the Official Methods
of Analysis of AOAC
INTERNATIONAL? Please specify
rationale.
,
.
meet the requirement of SMPR. In additional, the single laboratory validation result
was lack of certain data such as reference material, system suitability, LOQ etc.