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Reviewer Name:
Aniko Solyom
Email:
asolyom@gaasanalytical.comOrganization:
GAAS Analytical
Method Reviewed:
LUT‐01
Method Title:
Quantitative measurement of Beta‐ Cryptoxanthin in Paprika oleoresin, extract and
dietary supplements
Applicable SMPR
2016.004
Summary of Method:
The method quantifies the amount of beta‐cryptoxanthin and total xantophyllis in
paprika oleoresin, extracts and dietary supplement beadlets.
1. Does the Applicability of the
Method Support the Applicability
of the SMPR? If not, please explain
what is missing.
Partly. (i) According to the SMPR the method should be able to separately quantify
cis and trans isomers of each analytes ‐ the method quantifies beta‐cryptoxanthin,
without cis/trans distinction. (I believe the SMPR is a bit too ambitious with this
requirement.)
(ii) The method quantifies only beta‐cryptoxanthin but not the rest of the analytes
(lutein and zeaxanthin), but it can be still acceptable.
2. Does the analytical technique(s)
used in the method meet the
SMPR? If not, please specify how it
differs from what is stated in the
SMPR.
Yes
3. Are the definitions specified in
the SMPR used and applied
appropriatly in the method? If no,
please indicate how the terms are
used.
Yes
4. Does the method, as written,
contain all appropriate precautions
and warnings related to the
method's regaents, components,
instrumentation, or method steps
that may be hazardous? If no,
please suggest wording or
option(s).
There is no separate safety section in the description, but the chemicals and
instruments are commonly used in a routine analytical laboratory.
1. Are the definitions specified in
the SMPR used and applied
appropriately in the supporting
documentation (manuscripts,
method studies, etc…)? If not,
please explain the differences and
if the method is impacted by the
difference.
Yes, except the analytical range.
General Information
I. Summary
II. Review of the Method Only
III. Review of Information in Support of the Method