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Aerosol exposure
•
Based upon accidental laboratory inhalation
exposure
•
Symptoms noted within 90 minutes‐24 hours
after exposure
•
Symptomatic 3‐4 days
–
Fever
–
Headache
–
Muscle aches
–
Pulmonary symptoms
–
GI symptoms
Superantigenic properties of SEs
•
Cross link T‐cells with Antigen Presenting Cells
•
By‐passing antigen processing
•
Activates large populations of T‐cells
•
Release of cytokines
T i h k d
t
•
ox c s oc syn rome symp oms
•
Fever, hypotension vomiting, diarrhea, rash, renal failure
•
Associated with SEA, SEB, and SEC