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STAKEHOLDER PANEL ON Agent
Detection Assays
Background & Fitness for Purpose
Staphylococcal enterotoxin B
Sandra Tallent, PhD
h b l
Researc Micro io ogist US FDA
AOAC Rockville, MD
February 3, 2015
Background on Staphylococcal enterotoxins
•
Pyrogenic exoproteins
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Stable proteins
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Water soluble
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Heat resistant
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Protease resistant
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Tolerate extreme pH changes
•
Twenty‐three homologous serologically distinct
SEs identified
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SEA‐SEE select agent status
•
Superantigenic