Slide 1

Background

Challenges

•

Clinical Phase I studies have shown that the blood serum

levels of curcumin are in the ng/mL range after oral doses

of up to 8 g of curcumin, suggesting very low gastro‐

intestinal bioavailability

•

The reasons for the low oral bioavailability of curcumin are

not yet known

h i l i

bili (d d i

ili f li

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c em ca nsta ty egra at on pro ucts are van n, eru c ac ,

feruroyl methane)

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rapid metabolism

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poor absorption

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accumulation in cells of the gastro‐intestinal tract

Background

Analytical Needs

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Quantitative method for curcuminoids in

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Raw material (plant material without authentication)

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Extracts

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Finished products containing only turmeric and/or curcuminoids

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Finished products containing other ingredients (vitamins, other DS,

herbs)

•

Quantitative method for curcuminoids in

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Capsules

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Tablets

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Tinctures

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Softgel capsules