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SMPR Key Points
– Reference method for cGMP compliance
– Quantitation of each individual curcuminoid and
l l ti f th f i id ca cu a on o e sum o curcum no s
– Method performance requirements:
Parameter Requirement
Limit of Quantitation (LOQ) (%) ≤ 0.1
Recovery (%) 97 – 103
Analytical Range (%) ≤ 0.1 – 50 > 50
% RSDr ≤ 4 ≤2
% RSDR ≤ 6 ≤ 3
SMPR Key Points
Possible Interferences
– Piper nigrum
– Zingiber officinale (ginger)
– Capsicum annuum (cayenne pepper)
– ‐carotene
– Lutein
– Lycopene
– Zeaxanthin