1511 / 1983
Multivariate analysis of CBC
(Cox's model)
RR
IC 95%
p
Controls
1
< 10
-3
Non carriers
1.9
[1.1-3.2]
BRCA1/2
mutation
carriers
5.2
[2.6-10.4]
On multivariate analysis the BRCA mutation status was the only significant
predictor for the risk to develop contralateral cancer (p<10
-4
).
Age, lymph node status, hormonal receptor status, and tumour grade were not
significant predictors of local recurrence.