1522 / 1983
Association of risk reducing surgery in
BRCA1
or
BRCA2
mutation carriers with cancer risk and mortality
Domchek et al. JAMA, 2010
Prospective, multicenter cohort study of 2482 women
BRCA1/2
mutation
carriers ascertained between 1974 and 2008 and followed up until
December 2009
Control group with no prophylactic mastectomy underwent mammography
and MRI surveillance (until 50 yrs in the UK).
Mean follow up: 4 yrs
Domchek et al, 2010