478-479 / 1983
Introduction 2
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Evidence-base is small enough
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Balancing unequal considerations
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Early RT in LGG: Seizures:
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PFS; OS; Cognition; Fatigue
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Good example of both strengths and weaknesses of EBM
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Meta-analysis showed benefit of chemo in HGG pre-Stupp – not used
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Much decision-making is non-evidence based
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Trials are partial, and address only some of the questions
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Sometimes with long lead times and ignoring other evidence
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E.g. RTOG 98-02