

Some notation
•
Intervention A vs B improves OS, but is more likely to lead to grade 3 -
4 toxicity
•
A >
OS
B
•
A <
Grade3-4
B (n.b: A < B in the sense that it is worse)
•
In patients with disease D, having high F is associated with a better
survival than low F.
•
Patients D, High F >
OS
Low F