484-485 / 1983
Some examples
•
In patients with GBM:
•
Chemo-RT leads to a longer survival than RT alone (Stupp, 2005)
•
Chemo-RT is more toxic than RT, esp. haematological toxicity (Stupp, 2005)
•
MGMT-methylation is associated with improved survival (Hegi, 2005)
•
In patients with GBM
•
CRT >
OS
RT
•
CRT <
Grade3-4
RT
•
GBM and CRT; MGMT-meth >
OS
MGMT-unmeth