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Reliability of radiobiological evaluation
•
Solution 1: different populations, different parameters
to be used in dose-response model (Lyman)
1.0
0
0.5
0
40
80
120
Dose [Gy]
NTCP [*100 %]
Sequential CRT
Concomitant CRT
TD
50
46 (42 – 50)
TD
50
36 (34 – 56)
50
2.7 (1.25 – 5)
50
0.95 (0.71 – 1.11)
a
3.4 (2.4 – 5)
a
11.1 (1.3 – 14.3)
J Zhu et al. Analysis of acute radiation-induced esophagitis in non-small-cell lung cancer
patients using the Lyman NTCP model. Radiother Oncol (2010) 449–454.