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Parameters for clinical outcome: Small bowel
TF Lee et al. The Different Dose-Volume Effects of Normal Tissue Complication
Probability Using LASSO for Acute Small-Bowel Toxicity during Radiotherapy in
Gynecological Patients with or without Prior Abdominal Surgery.
BioMed Research International Volume 2014, Article ID 143020.
Small bowel toxicity in patients with GYN tumors undergone or not
to abdominal surgery:
1) 95 patients with GYN malignancies
2) 34 patients after surgery, 61 patients without prior surgery
3) Use of LASSO for modeling logistic regression over Vdose parameters
TV
50
=
tolerance volume corresponding to 50% incidence of complications
V
=
volume of small bowel receiving a given dose level
=
normalized slope of the volume response curve
1
4
50
ˆ
1
1
1
−
−
+ =
+
=
V
TV
e
NTCP
X