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Parameters for clinical outcome: Rectum
Volume
segmented
Irradiation type
(partial organ unless
otherwise stated)
Endpoint
Dose (Gy), or
dose/volume
parameters
Rate (%)
Notes on dose/volume
parameters
Whole organ
Whole organ
Whole organ
Whole organ
Whole organ
3D-CRT
3D-CRT
3D-CRT
3D-CRT
3D-CRT
Grade > 2 late rectal toxicity,
Grade > 3 late rectal toxicity
Grade > 2 late rectal toxicity,
Grade > 3 late rectal toxicity
Grade > 2 late rectal toxicity,
Grade > 3 late rectal toxicity
Grade > 2 late rectal toxicity,
Grade > 3 late rectal toxicity
Grade > 2 late rectal toxicity,
Grade > 3 late rectal toxicity
V50 <50%
V60 <35%
V65 <25%
V70 <20%
V75 <15%
<15
<10
<15
<10
<15
<10
<15
<10
<15
<10
Prostate cancer
treatment
•
Rectal segmentation from above the anal verge to the turn into sigmoid colon
•
The evaluation of
rectal bleeding
seems to have an
a
higher lower than other
endpoints (11)
•
The reduction of V75 from 15% to 10% is more effective than reduction of V50 from
50% to 45% respectively
Michalski JM et al. Radiation Dose-Volume effects in radiation-induced rectal injury.
Int. J. Radiation Oncology Biol. Phys., Vol. 76, No. 3, Supplement, pp. S123–S129, 2010.