293 / 1161
T Rancati et al. Inclusion of clinical risk factors into NTCP modeling of late rectal toxicity
after high dose radiotherapy for prostate cancer. Radiother Oncol 100 (2011) 124–130.
Parameters for clinical outcome: Rectum
Multivariate modeling for detecting rectal toxicity (G3 late rectal bleeding)
;
1
1
50
k
EUD
TD
NTCP
+
=
Logistic regression:
n
i
n
i
i
Dv
EUD
=
1
n
:
0.046
TD
50
: 93.1
Gy
k
:
10.4
TD
50
: 82.5
Gy
TD
50
: 91.7
Gy
Surgery+ TD
50
=
82,5 Gy
< Surgery- TD
50
=
91,7 Gy
Isoeffective
TD
50
is
11%
lower for Surgery+