Course book Advanced Treatment Planning 2018

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Parameters for clinical outcome: Rectum
• Dose-Volume histogram (DVH) against Dose-Wall Histogram (DWH)
• Toxicity scored with a modified RTOG score
• Endpoint G2 or higher within 2 years from the end of the treatment
Tucker SL et al. Comparison of rectal dose-wall histogram versus dose-volume histogram for
modeling the incidence of late rectal bleeding after radiotherapy. Int J Radiat Oncol Biol Phys
2004;60:1589–601.
DWH better predicts Rectal Toxicity than DVH
The difference in model accuracy is not so high
AvAUCDVH = 0,73
AvAUCDWH = 0,76