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X-rays
10
Cell nucleus
Carbon Ions
„Clustered DNA damage“
Local Microscopic Dose Distribution
„Randomized DNA damage“
Krämer & Kraft 1994
Physics meets biology
Linear Energy Transfer
(LET)
Density of ionization
in particle tracks is described
Definition:
average energy deposition (keV)
per traversed distance (1 µm)
low-LET
< 20 keV/µm
high-LET
> 20 keV/µm