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X-rays

10

Cell nucleus

Carbon Ions

Microscopic structures

„Randomized DNA damage“

Physics meets biology

DNA:

Propidium Iodide

Localization of MRE 11B, the core

protein of the MRE11B/RAD50/NBS1

DNA repair complex

human fibroblasts irradiated with

bismuth ions (4.1 MeV/nucleon)

Jakob et al. Radiat

Res 159: 2003

MRE11B

„Clustered DNA damage“