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Short DNA
fragments are
unable
to be
bound by the Ku70/Ku80
heterodimer
leaving a higher proportion of damage
More
homologeous repair
for DSBs
compared to gamma rays and protons
Rad Res. 2010
XRCC
Ku70 Ku70
Ku80
Ku80
DNA-PK
Ligase
Non-homologeous endjoining (NHEJ)
High LET radiation release dramatically
more
short DNA fragments
(100 to 2000 base pairs)
(Carbon Ions)
Particle effects on DNA damage and repair