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Differential signal activation ?
Classical mode High-LET mode
Cells treated
in vitro
with high-LET radiation
can enter apoptosis
through the activation
of
Caspase-9
,
regardless of the
presence or absence of
a functioning p53
Mechanism:
Mori et al. J Radiat Res 50: 2009
Particles: effect on cell inactivation
(Carbon Ions)