(Carbon Ions)
Particles: effect on cell cycle
Matsumura et al. 2003
Cell cycle distribution after 1.5 Gy
X-rays
Carbon ions
[75 keV/µ]
P
e
r
c
e
n
t
o
f
c
e
ll
s
i
n
G
2
M
-
p
h
a
s
e
o
Time after irradiation (hours)
Time after irradiation (hours)
[%] G2/M-phase
[%] apoptosis
human lymphoblastoid cell line TK6
longer lasting G2/M
arrest !
Protons:
experimental evidence for cell cycle
disturbation not consistent !!!!!!!!