606 / 1119
BOWEL (acute toxicity):
dose-volume effect
When:
V40
<170 cc
V45
<100 cc
V50
< 33 cc
the incidence of toxicity drops from 21% to 3%
175 pts, 12% of acute Gr2-3 toxicity
Fiorino IJROBP
2009
Rectal cancer patients + concomitant
chemotherapy ,acute G3 diarrhea
Robertson IJROBP
2010
Impact of
V15
AS A GEOMETRICAL SURROGATE of the HIGH
DOSE (larger difference at low dose in the DVH )
NO BIOLOGICAL MEANING - DONT USE IT
ALONE FOR IMRT OPTIMIZATION
Impact of V15 and
V40