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R-CVP versus R-CHOP versus R-FM as first-line therapy for
advanced-stage follicular lymphoma: Final results of FOLL05 trial
from the Fondazione Italiana Linfomi (FIL).
Federico et al
J Clin Oncol 2013
• Randomized trial comparing R-CVP with R-CHOP and R-FM.
• 534 patients were enrolled; 30 excluded. Median age 56 years
(range 30-75), 63% stage IV disease, 37% had 3-5 FLIPI and 27%
3-5 FLIPI2 scores.
• ORR (CR+ PR) for whole group was 91% (p=0.247). After median
follow-up of 34 months, 208 events for TTF were recorded;