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WWW.AOAC.ORG

301.924.7077

3:30 PM – 5:00 PM

TDRM Symposium: CRMs & RMs — What is the Difference and

What Does My Lab Need?

Reference materials (RMs) are essential tools for the analytical

laboratory. Certified reference materials (CRMs) and RMs are used to

assess the quality of measurements and the applicability of methods.

However, end users often have questions on how to use a CRM, how

to know that they have gotten the “correct” answer for a specific

measurand, and “Why does it take so long to produce a CRM?”. Even

with answers to these questions, it is not always possible to find a CRM

or RM with the “perfect” matrix. End users are left with the task of

making their own in-house materials and questions about how to do it.

In this session, the design, production, and certification of CRMs will

be discussed alongside the selection and use of CRMs. Finally, we will

discuss the value of producing an in-house reference material and how

to use CRMs for value assignment of in-house reference materials.

CO-CHAIR:

Laura Wood,

National Institute of Standards and Technology

CO-CHAIR:

Catherine Rimmer,

National Institute of Standards and

Technology

Mitzi Rettinger,

Cerilliant Corporation

The Importance of Certification and Preparation of Reference

Materials: Dietary Supplements and Cannabis

Håkan Emteborg,

European Commission – Joint Research Centre

Preparation of a PM2,5-like Reference Material Mimicking

Atmospheric Fine Dust: How Difficult Can It Be and Why Did It

Take So Long?

Pearse McCarron,

National Research Council Canada

The Complimentary Roles of Certified and In-House Reference

Materials for Biotoxin Measurements in Seafood

Eric Gordon,

Covance Laboratories Inc.

The Application of Certified Reference Materials and In-House

Reference Material in the Quality Control, Validation and

Harmonization of Methods across Multiple Test Sites

Challenges in the Shift to Color Additives from

Natural Sources: Regulation and Chemistry

Color additives (both synthetic and those derived from natural

sources) used in food and cosmetic products in the United States and

internationally are often complex formulations. In the changing world of

consumer perception of color additives, there has been a shift to color

additives from natural sources and has impacted the regulatory world of

color additives. There is a need for a global stage where science based

data, knowledge, and information can be shared. This AOAC Scientific

Session provides initial briefings that speak to the challenges on both

the regulatory and analytical scientific fronts and to further develop our

AOAC Community on Cosmetics and Color Additives.

CHAIR:

Bhakti Petigara Harp,

U.S. Food and Drug Administration,

Center for Food Safety and Applied Nutrition

George Pugh,

The Coca-Cola Company

Naturally Sourced Colors: Proactive Strategies to Support their Safety

Carol Locey,

Kalsec

Advances in Natural Red Colors from Beets

Monica Giusti,

The Ohio State University

The Chemistry of Anthocyanins: Diverse Structures for a

Colorful World

Maria Bastaki,

International Association of Color Manufacturers

Safety Data Requirements for Color Additives from Natural Sources

Novel Analytical Approaches to Manufacturing QC in the Dietary

Supplement and Food Industries

The average consumer’s awareness and expectations of the quality

and nutritional content of their favorite foods, beverages and dietary

supplements are certainly higher than ever before. Addressing both

the sensitivity these customers have for the composition of dietary

supplements and foods as well as an increasingly expansive regulatory

landscape presents a variety of scientific and operational challenges for

manufacturers around the world. Due to the natural sample complexity,

chromatography and mass spectrometry techniques are desirable in

both research and QC laboratories. Mass detection is widely recognized

as a reliable technique to derive more meaningful information

from food and dietary supplement samples and is an orthogonal,

complementary technique to optical detection. In order to offer

laboratories the opportunity to capture the benefits of mass detection

without the challenges typically associated with mass spectrometers;

recent advances in technology have focused on improving instrument

usability and robustness. Scientists now have the ability to generate

information-rich mass spectral data which complements data from

optical detectors such as photo diode array (PDA), tunable ultraviolet/

visible (TUV), evaporative light scattering (ELS), and fluorescence (FLR).

In this session, four industry leaders will share their experiences and

approaches to testing dietary supplements and food ingredients, with

a focus on analytical techniques that show great potential in solving

today’s scientific and operational challenges in the industry.

CO-CHAIR:

Joe Romano,

Waters Corporation

CO-CHAIR:

Amit Chandra,

AMWAY

James Traub,

Herbalife International of America Inc.

Benefits of Mass Detection for the Routine Analysis of

Nutritional Supplements

Bertil Nshime,

AMWAY

Mass Detection for Routine QC Analysis of Beauty and

Nutrition Products

Mekile Vuyani

Analysis of Water Soluble Vitamins in Animal Feed and Human Food

Jane Guido

Quantitation of Capsaicinoids by UPLC/MS Using Single Quadrupole

Mass Spectrometry in the QC Environment