162 / 1173
Cervix
author
n, treatment
result
comment
Jain
76, Rx
n.s.
no correlation with either p53 or bcl-2
Gasinska 130, Rx
n.s
AI/MI index significant
Lee
86, ?
n.s.
correlation with progression, MVD, Ki-67 but not OS
Kim
42, Rx
sig
high AI poor LTC, OS
Liu
77, Rx
sig
high AI (or Ki-67) poor OS no corr with IATs
Zaghloul
40, Rx
sig
low AI poor OS (or high vascularity)
Paxton 146, Rx
n.s.
high prolif or grade significant
NSCLC
Hanaoka 70, surg
n.s.
no correlation with bcl-2 or bax or ratio
Wang
58, surg
sig
low AI worse OS inverse correlation with bcl-2 and TA
Hwang
68, surg
sig
low AI worse OS also high bcl-2 worse OS
Macluskey ?, ?
sig
low AI worse OS
Langedijk
161, Rx
sig
high AI worse LTC, OS no correlation with bcl-2
Breast
Srinivas
?, ?
sig
high AI worse DFS, OS
Kato
422, ?
n.s
correlated with p53 and MI
Ikpatt
585, ?
n.s.
only MI and grade significant
Villar
116, surg
sig
high AI worse survival inverse corr with bcl-2
Lee
82, ?
n.s.
positive correlation with PCNA
Wu
91, CTX
sig
low AI worse RFS and OS
de Jong
172, ?
sig
high AI worse OS positive correlation with MI
Lipponen
288. ?
sig
high AI worse OS
Rectum
Sogawa
75, pre Rx
n.s.
AI increased after Rx but not correlated with OS
Schwander 160, surg
n.s.
inverse correlation with p53 and bcl-2
Bladder
Giannopolou 53, ?
n.s
no correlation with pro-apoptotic proteins bax, FAS-R casp-3
Moonen
83, Rx
n.s.
high AI better LTC not OS, low AI shorter time to reccurrence
Lara
55, Rx
sig
low AI better LTC and OS
Esoph
Rees
58, Rx, CTX, surg n.s
only TOPO II and not AI or Ki-67 showed clinical utility
Shibata
72, surg
sig
high AI better OS
Results
6 better outcome with high AI
8 worse outcome with igh AI
13 not significant
Apoptotic index and prognosis in cancer
All studies using morphology or TUNEL since 2000
(Wilson, 2003)