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Conclusions
• Most cell death is controlled or programmed in some way.
– Major pathways include apoptosis, senescence, autophagy and
necrosis
• Measuring one form of cell death (eg Apoptosis) will not
necessarily correlate with how many cells die
– Cell may die by other mechanisms
• The form of cell death may influence the rate at which cells
die
– Affect tumor regression
• Genetic changes may dramatically alter how cells die
without changing if they will die