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2
Framework
3
Kaelin Nat Rev 2005
Target
driven
lethality
(Oncogene addiction)
Synthetic
lethality
Contextual
synthetic
lethality
Targeting the hallmarks of cancer
•
High specificity
•
Low toxicity (different from RT)
•
Interaction with RT
•
Radiosensitivity
•
Hypoxia
•
Proliferation
•
Immune activation
•
High therapeutic index
4
Hanahan & Weinberg Cell 2011