664 / 1173
1/03/2016
3
Target driven lethality
5
Target driven lethality
•
High specificity
•
Low toxicity (different from RT)
•
Interaction with RT
•
Radiosensitivity
•
Hypoxia
•
Proliferation
•
Immune activation
•
Therapeutic index
•
Target driven
•
Synthetic lethality
•
Contextual lethality
6
Hanahan & Weinberg Cell 2011