669 / 1173
1/03/2016
8
Study treatment
Study treatment
•
Arm 2 – Radiation therapy + Cetuximab
•
Cetuximab
•
Week 1 (no radiation): 400mg/m² IV
•
Week 2-8: 250mg/m² IV followed by radiation *
*Radiation therapy – cfr. previous slide
•
Post-radiation neck dissection
•
Recommended for >N1 neck disease
Bonner et al NEJM 2006
56
26
18
56
27
17
RT fractionation
Concomitant boost
Once-a-day
Twice-a-day
72 / 28
72 / 28
T-stage: T1-3 / T4
20 / 80
19 / 81
N-stage: N0 / N+
67 / 33
67 / 33
KPS: 90-100 / 60-80
(%)
(%)
Stratification factors
N=211
N=213
Patients randomized
RT+c225
RT
Patient Randomization
Randomization
Bonner et al NEJM 2006