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EGFR inhibition + RCT in HNSCC
•
Benefit with
chemotherapy
?
•
RTOG0522
•
Randomized Phase III
•
Concurrent accelerated radiation and cisplatin vs concurrent
accelerated radiation, cisplatin and cetuximab
•
Stage III and IV HNSCC
•
Initial results: Cetuximab did not improve PFS or OS and was
associated with higher rates of mucositis and skin reactions.
EGFR inhibition + RCT in HNSCC
•
Benefit with
chemotherapy
?
Ang KK, J Clin Oncol. 2011;29, ASTRO