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EGFR inhibition + RCT in rectal cancer
•
Importance of translational research
27
Debucquoy JCO 2009
EGFR inhibition + RCT in rectal cancer
•
CRT might have been compromised by cetuximab
pretreatment
•
Pre-CRT initial dose of
cetuximab decreased tumor
cell proliferation
•
Capecitabine needs to
be taken up by proliferating
cells to exert its effects
28
Debucquoy JCO 2009