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Contextual lethality
•
High specificity
•
Low toxicity (different from RT)
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Interaction with RT
•
Radiosensitivity
•
Hypoxia
•
Proliferation
•
Therapeutic index
•
Target driven
•
Synthetic lethality
•
Contextual lethality
•
Immune modulation
Hanahan & Weinberg Cell 2011
Tumor vasculature as a target
•
Angiogenesis inhibiting agents
•
Target angiogenesis process
•
E.g. bevacizumab