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Synthetic lethality
•
High specificity
•
Low toxicity (different from RT)
•
Interaction with RT
•
Radiosensitivity
•
Hypoxia
•
Proliferation
•
Immune activation
•
Therapeutic index
•
Target driven
•
Synthetic lethality
•
Contextual lethality
29
Hanahan & Weinberg Cell 2011
Synthetic lethality
30