678 / 1173
1/03/2016
17
Clinical trials: PARP inhibitors + radiotherapy
•
Several ongoing trials (clinical trials.gov)
•
Veliparib With Radiation Therapy in Patients With
Inflammatory or Loco-regionally Recurrent Breast
Cancer
•
Olaparib and Radiotherapy in Inoperable Breast Cancer
•
Olaparib and Radiotherapy in Inoperable Breast Cancer
•
A Trial Evaluating Concurrent Whole Brain Radiotherapy
and Iniparib in Multiple Non Operable Brain Metastases
•
…
33
Contextual lethality
Hypoxia
pH, lactate
Glucose,
Glutamine
Micro-
environment