788-789 / 1173
ESTRO
Treatment of advanced squamous-cell carcinoma of the head
and neck with alternating chemotherapy and radiotherapy.
M. Merlano et al, NEJM, 327:1115-1121, 1992.
Enhancement factor
Effect on tumor control
Effect on normal
tissue toxicity
Early
Late
2
1
2
Local
relapse
?
RT: 70 Gy, 7 weeks
RT+CH: 3 x 20 Gy, 9 weeks;
cddp (20mg/m
2
/d, d1-5)-5Fu (200 mg/m
2
/d, d1-5) x4