893 / 1816
no PMRT
PMRT
Events All
no PMRT
PMRT
HR = 1.10 (0.15 to 7.83)
2 25
2 24
P= 0.93
0
25 50 75
100
Loco-regional control (%)
0 24 48 72 96 120144168192216240
Time after treatment (months)
Low index
High index
Events All
Low index
High index
HR = 0.09 (0.02 to 0.37)
39 70
2 25
P=3.0 x10-5
0
25 50 75
100
25 23 18 14 11 9 9 8 8 4 0
High index
70 39 22 17 15 12 12 12 9 5 2
Low index
At risk
0 24 48 72 96 120144168192216240
Time after treatment (months)
Results
Patients split in quartiles
according to size of 7-gene-
index
High index
= 25% of
patients with highest index
Low index
= 75% of
patients with lowest indexes
Prognostic
(no PMRT group)
Predictive
Low index
High index
0 24 48 72 96 120 144 168 192 216 240
31%
no PMRT
PMRT
Events All
no PMRT
PMRT
HR = 0.16 (0.09 to 0.34)
39 70
9 76
P= 2.6 x10-8
0
25 50 75
100
0 24 48 72 96 120144168192216240
Time after treatment (months)
90%
31%
85%
86%
90%
0 24 48 72 96 120 144 168 192 216 240
0 2 48 7 9 12 14 1 19 2 2
This pattern is seen regardless of
-nodal status
-T status
-menopausal status
The gene profile has been
validated in an independent data
set
(Tramm et al, Clin Can Res, 2014)