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Potential of gene analysis studies
03/01/13
The DBCG 7 gene profile can predict gain from loco-regional RT after
mastectomy. It identifies 25% of a high-risk cohort where RT may not be of any
value. This gene profile is predictive of RT effect.
The Michigan 51 gene profile can discriminate patients treated with BCS+RT who
are unlikely to develop local recurrence after RT from those patients with a high
likelyhood of recurrence despite RT. Thus it may identify patients who need
treatment intensification. This gene profile is prognostic (not predictive).
Further studies are being performed to explore the potential of these profiles.