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Clin Can Res, 2015
1) In vitro: Clonogenic survival assays to identify the SF-2Gy in 16 BCC lines
2) Surviving fractions (17-77%) independent of intrinsic subtypes
3) Gene expression data from BCC correlated to SF data, 147 genes identified
4) Hierarchical cluster analysis separates genes into radioresistent vs –sensitive
5) In vivo: RSS run in test set of 343 pts with gene analysis data, all treated with
BCS+RT and with FU, then RSS further trained and refined to 51 genes.
6) 51 gene profile evaluated on
ingenuity.com,tested in a validation set of 295 pts
with gene analysis data and with BCS+RT and FU
Genes involved in
cell cycle
DNA damage
DNA repair