Step 4: Clinical validation study
Identical prospective data collection
Assessment
T0
Weekly
during
RT
After completion of
radiotherapy
6
wks
6
mos
12
mos
18
mos
è
60
mos
Acute
toxicity
+ + +
Late toxicity
+
+ + + +
PROMs
+ + + + + +
yearly
Analytic
endpoints
+
+ +