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STEP 3: Integrate step 1 and 2

Translate Δdose

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ΔNTCP

0%

10%

20%

30%

40%

50%

60%

70%

0 10 20 30 40 50 60 70

Mean dose PCM superius

NTCP (%)

Dmean supraglottic = 10 Gy

Dmean supraglottic = 20 Gy

Dmean supraglottic = 30 Gy

Dmean supraglottic = 40 Gy

Dmean supraglottic = 50 Gy

Dmean supraglottic = 60 Gy

Dmean supraglottic = 70 Gy

St-IMRT

SW-IMRT

superior PCM

Langendijk, et al. Radiother Oncol 2013

0%

2%

4%

6%

8%

10%

12%

14%

D

NTPC

Patients

ΔNTCP

different in

each individual

patient