Quantitative Methods 2017

Previous Page

Next Page

Page Background

Model-based approach

4 steps

STEP 1: NTCP model

–

Multivariable NTCP-models

STEP 2: Individual dose comparison

–

Dose reduction (

D

Dose

): relevant DVH

parameters?

STEP 3: Estimate NTCP reduction (ΔNTCP)

–

Translate

D

Dose

to

D

NTCP

STEP 4: Validation

–

External validation NTCP-model with new

technology

Langendijk, et al. Radiother Oncol 2013