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Maximum likelihood
•
Define contributions to the likelihood function as
function of n,
50
, D
50
•
For patients experiencing toxicity:
•
For patients
not
experiencing toxicity:
•
Total likelihood function:
Tox i
D n
p
L
toxicity
i
),
, ,
(
50
50
Tox i D n p
L
toxicity
i
),
, ,(
1
50
50
) ,
,(
)
,
,
(
50
50
50
50
D nL
D nL
L
Tox i
i
Tox i
i