598-599 / 1676
598-599 / 1676
Maximum likelihood
•
The values of n,
50
, D
50
maximizing L are the most
likely predictors of toxicity
) ,
,(
) ,
,(
50
50
50
50
D nL
D
n
L
L
Tox i
i
Tox i
i
Tox i
D n p L
toxicity
i
),
, ,(
50
50
Tox i D n p
L
toxicity
i
),
, ,(
1
50
50
