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of dietary supplement (and foods), botanical suppliers
dealing with FSMA requirements, and regulatory experts.
The discussion is expected to be free-wheeling and will
range from identity testing requirements, “reasonably
anticipated contaminants”, standard operating procedures,
“verification or validation”, and qualification of standards
and reference materials. The ultimate goal of the session
is to put manufacturers, analytical test methods / analysts,
contract labs and regulatory officials in the same room so
that fruitful discussions can take place involving real time
challenges / issues and recommendations of solutions to
curtail them.
CO-CHAIR:
Amitabh Chandra,
AMWAY
CO-CHAIR:
Joseph Betz,
National Institutes of Health
•
Presenters TBD
WEDNESDAY, SEPTEMBER 21, 2016
8:15 am – 9:45 am
Mycotoxin News—Ready for the Future
Mycotoxin contamination in food and feed poses a
serious threat for human and animal health. For this
reason, numerous countries have introduced regulatory
limits. Highly precise analytical methods are needed to
enable reliable controls of the maximum limits of these
compounds. In recent decades, mass spectrometry based
methods like LC-MS/MS have gained importance and
can now be considered as the most accurate tools for
mycotoxin analysis. Due to the high sensitivity, selectivity,
and accuracy of these methods, as well as the increased
availability of isotope labeled internal standards, a wide
range of analytical methods using LC-MS/MS are rapidly
being developed. These new approaches are replacing
more traditional methods such as HPLC or TLC. Innovative
isotopic labeled internal standards in combination with
efficient clean-up prior to LC-MS/MS analysis make it
possible to overcome matrix effects and ion enhancement/
suppression effects. In addition, a variety of mycotoxins
can now be analyzed simultaneously using LC-MS/MS
multi-analyte methods.
This session will discuss various approaches for the
implementation of LC-MS/MS methods for mycotoxin
analysis in food and feed. This session will focus on multi-
analyte method development and will give some insight
into the regulations and changes during recent years.
CO-CHAIR:
Joerg Stroka,
JRC-Geel
CO-CHAIR:
Lilian Kuster,
Romer Labs Division
Holding GmbH
•
Jon Wong,
U.S. Food and Drug Administration
Perspective on Advancing FDA Regulatory Monitoring
for Mycotoxins in Food Using Liquid Chromatography
and Mass Spectrometry
•
Alois Schiessl,
Romer Labs Division Holding GmbH
LC-MS/MS Multi Mycotoxin Developments in
Routine Labs
•
Michael Sulyok,
University of Natural Resources and
Life Sciences, Vienna
Analytical Performance of an LC-MS/MS Based “Dilute
and Shoot” Approach for Multi-Mycotoxin Analysis
•
Joerg Stroka,
JRC-Geel
Method Performance for Mycotoxins: What Can We
Conclude from the Last Decade?
•
Tetsuhisa Goto,
Retired from Shinshu University
Mycotoxin Regulation in Pet Food and Feed in Japan
Food Allergen and Gluten Analysis by LC-MS:
Where Are We?
Food allergies and intolerance to gluten are important
health concerns worldwide with the only prescription
being the complete avoidance of the specific food proteins
in order to eliminate the risk of an adverse reaction.
Analytical methods are a key component in allergen
control programs and in the enforcement of regulatory
requirements. Immunological based methods such
as enzyme-linked immunosorbent assays (ELISA) are
important tools for the detection and quantification of
food allergens, but due to limitations with some matrices
and processing methods (e.g. hydrolyzed and fermented
foods) there is a need for alternative confirmatory methods
of analysis. Mass spectrometry (MS) methods coupled
to liquid chromatography (LC) are being developed that
directly measure selected marker peptides from food
allergens. These tandem mass spectrometry experiments
(LC-MS/MS) have the potential for both qualitative and
quantitative determination of multiple food allergens in
one analysis with a specificity that cannot be achieved
by antibodies. This session will provide an update on the
status of these promising mass spectrometry methods from
different international laboratories using an assortment of
different instrument technologies.
CO-CHAIR:
Jerry Zweigenbaum,
Agilent
Technologies, Inc.
CO-CHAIR:
Terry Koerner,
Health Canada