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Principles of WHO lymphoma
classification
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Aims to define clinically relevant entities
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Diagnosis based on integration of clinical, histological,
immunophenotypic and genetic features
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Basic division into ‘precursor’ and ‘mature’ (or
‘peripheral’) lymphomas. Then by lineage (B/T/NK-cell)
•
Thymus and bone marrow are primary sites of precursor
T- and B-cell development
•
‘Peripheral’ sites are deep and superficial lymph nodes
and extranodal (e.g., mucosal) lymphoid tissues