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What does immunophenotype tell us?
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In the context of appropriate (consistent) histology:
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Lineage and sub-lineage: B-/ T-/NK-cell, CD4/CD8 T-cells,
CD10+/MUM1+ B-cells
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Characterisation of accompanying reactions (histiocytes
and histiocyte-derived dendritic cells, mesenchyme-derived
dendritic cells, mucosal lympho-epithelial interactions)
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May reinforce architectural features: e.g. revealing subtle
nodularity (potential follicularity)
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Some cellular immunophenotypes are defining