449 / 1498
Phase I/II Trial of TLI vs High-Dose Chemotherapy
Salvage Regimen
• Patients with primary refractory/relapsed HL (n=48; 1993-2005)
• Conditioning regimen:
– TLI/chemotherapy
– Chemotherapy-alone (if prior RT >2000cGy had been given)
• TLI details:
– Accelerated hyperfractionated TLI 150cGy x10
– Boost to previous and current disease to 150cGy x10
– BID regimen
– Pre-transplant
• Chemotherapy regimen:
– Carboplatin
– Cyclohosphamide
– Etoposide
Evens et al., Ann Oncol 2007