Flipping Book - Hema

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Established definitions of when treatment required
Patients with at least one of the following requiring initiation of
treatment:
– Bulky disease (nodal or extranodal mass > 7cm)
– B symptoms
– Elevated serum LDH (> ULN) or β2-microglobulin (> 3mg/L)
– Involvement of ≥ 3 nodal sites (each > 3 cm)
– Symptomatic splenic enlargement, compressive syndrome,
pleural/peritoneal effusion