866 / 1498
PMBCL diagnosis
basal PET-CT 1
Standard therapy
R-Chemo
PET-CT 2
Central review
Positive
Negative
Mediastinal RT 30
Gy
Observation
Random 1:1
5-6 wks after R-Chemo
8 wks after R-Chemo
Positive not randomised pts will be followed for
response, PFS and OS analysis of the chosen
salvage strategy
.
IELSG 37:
t
rial design
*
RCHOP 14-21; R-V/MACOP-B
DA-EPOCH-R; R-ACVBP;
R-CHO(E)P like
I
NTERNATIONAL
E
XTRANODAL
L
YMPHOMA
S
TUDY
G
ROUP
376 pts to randomize