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PMBCL diagnosis

basal PET-CT 1

Standard therapy

R-Chemo

PET-CT 2

Central review

Positive

Negative

Mediastinal RT 30

Gy

Observation

Random 1:1

5-6 wks after R-Chemo

8 wks after R-Chemo

Positive not randomised pts will be followed for

response, PFS and OS analysis of the chosen

salvage strategy

.

IELSG 37:

t

rial design

*

RCHOP 14-21; R-V/MACOP-B

DA-EPOCH-R; R-ACVBP;

R-CHO(E)P like

I

NTERNATIONAL

E

XTRANODAL

L

YMPHOMA

S

TUDY

G

ROUP

376 pts to randomize