330 / 1708
WNT Medulloblastoma
•
Very good prognosis
•
Long-term survival > 90%
•
Majority have classical histology
•
Beta-catenin nucleo-positivity,
CTNNB1
gene
mutations, and monosomy 6
•
Rarely the WNT subgroup may include large
cell/anaplastic cases. Can occur at all ages, but is
infrequent in infants
•
M:F ratio approximately 1:1